Inspired by the technique and efficacy of the micro-needling technology used in aesthetic medicine, the Biologique Recherche μ-Fill PIGM 400 Anti-dark-spot Patches use a triple action platform infused with brightening active ingredients to correct localized pigmentation in the skin. They form part of the Initialization Stage of Biologique Recherche’s three-step treatment protocol, helping to clear and correct the skin.
Each single-use μ-Fill PIGM 400 patch is covered with micro-cones made up of 100% solidified active ingredients that allow for highly targeted action on pigmentation in the epidermis. These powerful elements, including hyaluronic acid, solidified anti-melanogenesis, anti-glycation, and antioxidant ingredients, work together to visibly reduce the intensity of pigmentation marks. Once the patch is applied to the skin, the micro-cones dissolve completely to release the active ingredients close to the melanocytes – melanin-producing cells– that create the pigmentation in order to treat the problem at its source. Hyaluronic acid, a hero ingredient of the skincare industry, acts as a vector for the active ingredients in the micro-cones, optimizing their efficacy.
Of course, they say that the best offense is a great defense, which is why the fight against pigmentation should include preventative measures. For example, the daily use of high-factor sunscreen can provide powerful protection against UV rays, which can stimulate melanogenesis – or the creation of melatonin, which pigments the skin. But, once the skin has created pigmentation marks, successfully treating them requires targeting and reversing all the actions that go into melanogenesis. That’s where the Biologique Recherche μ-Fill PIGM 400 Anti-dark-spot Patches can help.
The targeted patches offer a wealth of benefits – they lighten the skin, stall melanogenesis, and regulate the melanin in the skin. With continued use throughout the one-month program, the μ-Fill PIGM 400 patches effectively reduce the pigment spots on the skin’s surface, leaving it brighter and more even.
See also: Biologique Recherche Unlocks the Secrets of Anti-Aging with New Collagène Originel Serum

How It Works
The innovative Biologique Recherche μ-Fill PIGM 400 Anti-dark-spot Patches are so powerful because they work on a triple-action platform that incorporates a multitude of active ingredients and actions.
The anti-glycation platform uses L-Carnosine, a hard-working peptide that helps to preserve the DNA of skin cells, allowing them to return to their natural state, and blocks the overproduction of melanin to reduce pigmentation marks.
Any skincare savant worth their salt knows just how powerful Vitamin C can be for maintaining healthy skin, and this is exactly why Biologique Recherche incorporates this ingredient into its μ-Fill PIGM 400 patches. The main product in the patches’ antioxidant platform, Vitamin C offers powerful antioxidant and photoprotective effects for enhanced lightening in the skin and the reduction of pigmentation.
The most potent part of the μ-Fill PIGM 400 patch, though, is its anti-melanogenesis platform, which includes several active ingredients that work in tandem to fight the production of melanin in the skin. These include Hexylresorcinol, which controls melanin production induced through oxidative stress; Niacinamide, which inhibits the transfer of melanin-storing melanosomes to cells in the epidermis; and Tranexamic acid, which limits the reactions which trigger melanin production. Together, these ingredients inhibit the formation of pigmentation marks before they happen and diminish those that already exist.
To reap the benefits of these μ-Fill PIGM 400 patches, you’ll have to first head to a Biologique Recherche center and undergo a skin analysis so that an aestheticist can identify your specific Skin Instant using the brand’s comprehensive dermo-cosmetic diagnostic process. The product is specifically recommended for those Skin Instants with localized pigmentation marks. If deemed suitable, you’ll use the patches on cleansed, dry skin three times a week for one month, leaving them on for at least three hours, or preferably overnight, each time.
Beauty aficionados will be excited to learn that there is a whole μ-Fill PIGM 400 range to go with the Biologique Recherche μ-Fill PIGM 400 Anti-dark-spot Patches including: Lotion P50 PIGM 400, Masque PIGM 400, Serum PIGM 400, Crème PIGM 400 and Emulsion Main PIGM 400.
Find Effective, Customized Skincare with Biologique Recherche
Created on Paris’s Champs Elysées by a family of artisanal skincare experts, Biologique Recherche has spent over 40 years becoming the leading name in targeted, personalized skincare driven by science, technology, and plenty of research. After launching its cult-favorite Lotion P50 in 1970, biologist and physiotherapist Yvan and Josette Allouche went on to create their line of exclusive skincare and cosmetic treatments that offer immediate, long-lasting results.
Over the years, the brand has also developed a unique system of diagnostic tools and protocols that help identify each client’s individual Skin Instant. The results help to create a highly individualized three-step treatment program using Biologique Recherche’s range of skincare products that are driven by concentrated botanical, marine, and biological active ingredients.
With its revolutionary Biologique Recherche μ-Fill PIGM 400 Anti-dark-spot Patches, the beauty brand redefines the way in which we address and treat pigmentation, offering an innovative solution that uses meticulous science and technology to deliver a flawless complexion.